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Mom and partner

Not actual patients.

What you need to know about postpartum depression

From check-ins with your healthcare provider to baby-proofing your home, you’re preparing for a lot. But there’s something you may not have prepared for: postpartum depression (PPD).


Eight moms

Approximately 1 in 8 moms experiences symptoms of postpartum depression

Postpartum depression is one of the most common medical conditions that can happen during or after pregnancy. But it can be hard to recognize.


Symptoms of postpartum depression

Having a baby changes your body and your life in ways that are hard to predict. Feeling exhausted, sad, moody, or tired within the first couple of weeks with your new baby can be common.

However, PPD is different. If you’re feeling depressed or you’re experiencing a lack of interest or pleasure in normal activities, these can be signs of PPD.

Below is a list of signs and symptoms commonly associated with PPD. These are not the only ones, and you do not need to have all of them to experience PPD. If you’re experiencing anything that is causing you concern, speak with your healthcare provider as soon as you can.

Mom holding baby

Signs and symptoms:

  • Persistent sad, anxious, or "empty" mood
  • Irritability
  • Trouble bonding or forming an emotional attachment with the new baby
  • Persistent doubts about the ability to care for the new baby
  • Feelings of guilt, worthlessness, hopelessness, or helplessness
  • Loss of interest or pleasure in hobbies and activities
  • Fatigue or abnormal decrease in energy
  • Difficulty concentrating, remembering, or making decisions
  • Difficulty sleeping (even when the baby is sleeping), awakening early in the morning, or oversleeping
  • Abnormal appetite, weight changes, or both
  • Thoughts about death, suicide, or harming oneself or the baby
  • Feeling restless or having trouble sitting still
  • Aches or pains, headaches, cramps, or digestive problems that do not have a clear physical cause or that do not ease even with treatment

Postpartum depression is not your fault

PPD can happen to anyone, regardless of age, ethnicity, marital status, or income. It is not a reflection of you as a mother, and it is not your fault in any way.

Mom sitting in a chair

Research shows there are some biological and environmental factors that may be associated with PPD, including:

  • Family or personal history of depression
  • Increased stressors
  • Hormone changes related to pregnancy

If you're concerned you may be experiencing PPD, speak with your healthcare provider as soon as possible.

Each Day Matters

You want to be there for your baby each and every moment, which is why it’s so important you take care of yourself, too.

Find out if there is a ZULRESSO Treating Center near you


Real moms, real stories: Learn more about the symptoms of PPD

PPD isn’t the same for everyone. Hear from women who experienced PPD to learn more about signs and symptoms.

Photo of Mom, Chelsey
Everything is just exhausting. Your everyday activities are just really stressful and hard. I would often feel like I didn’t have a place to fit. It’s hard when you’re in those moments to remember that you’re not alone.
Watch stories from real moms

ZULRESSO Patient Brochure.

Looking for more information about ZULRESSO and treatment? Download the Patient Brochure or share it.

Zulresso Patient Brochure

What is ZULRESSO?

ZULRESSO® is a prescription medicine used to treat Postpartum Depression in adults.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ZULRESSO?

ZULRESSO can cause serious side effects, including:

  • Excessive sedation and sudden loss of consciousness. ZULRESSO may cause you to feel very sleepy (excessive sedation) or pass out (loss of consciousness). Your healthcare provider should check you for symptoms of excessive sleepiness every 2 hours while you are awake.
    • During your ZULRESSO infusion, tell your healthcare provider right away if you feel like you cannot stay awake during the time you are normally awake or if you feel like you are going to pass out. Your healthcare provider may lower your dose or stop the infusion until symptoms go away.
    • You must have a caregiver or family member with you to help care for your child(ren) during your ZULRESSO infusion.

Before receiving ZULRESSO, tell your healthcare provider about all your medical conditions, including if you:

  • Drink alcohol
  • Have kidney problems
  • Are pregnant or think you may be pregnant. It is not known if ZULRESSO will harm your unborn baby.
    • There is a pregnancy registry for females who are exposed to ZULRESSO during pregnancy. The purpose of the registry is to collect information about the health of females exposed to ZULRESSO and their baby. If you become pregnant during treatment with ZULRESSO, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1‑844‑405‑6185 or visit https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/antidepressants/
  • Are breastfeeding or plan to breastfeed. ZULRESSO passes into breast milk. Talk to your healthcare provider about the risks and benefits of breastfeeding and about the best way to feed your baby while receiving ZULRESSO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

ZULRESSO and some medicines may interact with each other and cause serious side effects.

Especially tell your healthcare provider if you take other antidepressants, opioids, or Central Nervous System (CNS) depressants (such as benzodiazepines).

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine. Your healthcare provider will decide if other medicines can be taken with ZULRESSO.

How will I receive ZULRESSO?

ZULRESSO is given to you by continuous intravenous (IV) infusion into your vein. The infusion will last for a total of 60 hours (2.5 days).

What should I avoid while receiving ZULRESSO?

  • ZULRESSO may make you feel dizzy and sleepy. Do not drive a car or do other dangerous activities after your ZULRESSO infusion until your feeling of sleepiness has completely gone away. See “What is the most important information I should know about ZULRESSO?”
  • Do not drink alcohol while receiving ZULRESSO.

What are the possible side effects of ZULRESSO?

ZULRESSO can cause serious side effects, including:

  • See “What is the most important information I should know about ZULRESSO?”
  • Increased risk of suicidal thoughts or actions. ZULRESSO and other antidepressant medicines may increase suicidal thoughts and actions in some people 24 years of age and younger. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions.

How can I watch for and try to prevent suicidal thoughts and actions?

  • Pay close attention to any changes, especially sudden changes in mood, behavior, thoughts, or feelings, or if you develop suicidal thoughts or actions.
  • Tell your healthcare provider right away if you have any new or sudden changes in mood, behavior, thoughts, or feelings.
  • Keep all follow-up visits with your healthcare provider as scheduled. Call your healthcare provider between visits as needed, especially if you have concerns about symptoms.

Tell your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you:

  • Attempts to commit suicide, thoughts about suicide or dying, new or worse depression, other unusual changes in behavior or mood.

The most common side effects of ZULRESSO include:

  • Sleepiness, dry mouth, passing out, flushing of the skin or face.

These are not all the side effects of ZULRESSO.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please also see Full Prescribing Information including Boxed Warning and Medication Guide for ZULRESSO® and discuss any questions you may have with your healthcare provider.

ZULRESSO® is a prescription medicine used to treat Postpartum Depression in adults.
IMPORTANT SAFETY INFORMATION
ZULRESSO can cause serious side effects, including: Excessive sedation and sudden loss of consciousness. ZULRESSO may cause you to feel very sleepy (excessive sedation) or pass out (loss of consciousness). Your healthcare provider should check you for symptoms of excessive sleepiness every 2 hours while you are awake